reeshma ramesan
Supercomputer simulations at the Department of Energy's Oak Ridge National Laboratory are giving scientists unprecedented access to a key class of proteins involved in drug detoxification.
Nokia is all set to bid adieu to its Symbian branding. In a blog post, the Finnish company announced that its next version of Symbian OS will be called Nokia Belle. The latest move appears to be part of Nokia's drive to bring all its products under the Nokia product brand. Previously, Nokia had renamed its Ovi Store to Nokia Store. However, the company did not elaborate reasons behind the new OS name.
Supercomputer simulations at the Department of Energy's Oak Ridge National Laboratory are giving scientists unprecedented access to a key class of proteins involved in drug detoxification.
Jerome Baudry and Yinglong Miao, who are jointly affiliated with ORNL and the University of Tennessee, have performed simulations to observe the motions of water molecules in a class of enzymes called P450s. Certain types of P450 are responsible for processing a large fraction of drugs taken by humans.
The supercomputer simulations were designed to help interpret ongoing neutron experiments.
"We simulated what happens in this enzyme over a time scale of 0.3 microseconds, which sounds very fast, but from a scientific point of view, it's a relatively long time," Baudry said. "A lot of things happen at this scale that had never been seen before. It's a computational tour de force to be able to follow that many water molecules for that long."
The team's study of the water molecules' movements contributes to a broader understanding of drug processing by P450 enzymes. Because some populations have a slightly different version of the enzymes, scientists hypothesize that mutations could partially explain why people respond differently to the same drug. One possibility is that the mutations might shut down the channels that bring water molecules in and out of the enzyme's active site, where the chemical modification of drugs takes place. This could be investigated by using the computational tools developed for this research.
By simulating how water molecules move in and out of the protein's centrally located active site, the team clarified an apparent contradiction between experimental evidence and theory that had previously puzzled researchers. X-ray crystallography, which provides a static snapshot of the protein, had shown only six water molecules present in the active site, whereas experimental observations indicated a higher number of water molecules would be present in the enzyme.
"We found that even though there can be many water molecules -- up to 12 at a given time that get in and out very quickly -- if you look at the average, those water molecules prefer to be at a certain location that corresponds to what you see in the crystal structure," Miao said. "It's a very dynamic hydration process that we are exploring with a combination of neutron scattering experiments and simulation."
The simulation research is published in Biophysical Journal as "Active-Site Hydration and Water Diffusion in Cytochrome P450cam: A Highly Dynamic Process."
ORNL researchers used simulation to reveal how water molecules (seen in red) move in and out of the active site (seen in blue) of a P450 enzyme. This class of enzymes is responsible for detoxifying a large fraction of drugs taken by humans. (Credit: Image courtesy of DOE/Oak Ridge National
Johny James
Symbian name gets dropped
The Nokia Belle will be arriving in several Nokia smartphones including Nokia N8, Nokia E7, Nokia E6, Nokia X7, Nokia C6-01, Nokia C7, and Nokia Oro. The roll-out of the OS will begin in February 2012. The Nokia Belle update comes with various new features including more home screens. In addition, the home screen widgets have been revamped and given more functionality. The Nokia Belle update also makes reading e-mails and other texts on the smartphones easier.
“Launched earlier this year with Nokia 701, Nokia 700 and Nokia 603 smartphones, the UI [Nokia Belle] has received lots of positive feedback from our customers. The enhanced versions of Nokia N8, Nokia C7 and Nokia C6-01 have now started their journey from the factories to the shops with Nokia Belle preinstalled, arriving first in China, then around the world,” says Nokia in the blogpost.
AJAY PAUL
AJAY PAUL
Google Plus Vs Facebook
Social Networking always existed offline. But it was when that jumped to the online domain, things got interesting. According to the latest statistics, 54% of Indians online use the internet for Social Networking. With Facebook being the prime social website of choice and twitter fast catching up, the question begs to be asked is do we need another social network?
Well that question has been answered by Google Plus which is that latest kid on the block. Giving users a host of never before seen features, great UI and of course Google’s integration; Google Plus comes across as a great alternate to your Facebook loving ways. Its astronomical growth also tells a compelling story on how well it’s been accepted by netziens. All reasons why I decided to do a bit of digging around to bring you a bunch of interesting stats dolled up infographic style.
http://www.oneclickcustomers.com/infographics/google-vs-facebook-infographic.html
Mithun Mathew
Intel Ivy Bridge
Ivy Bridge is the codename for the 22 nm die shrink of Sandy Bridge
Intel plans for retail sale in 2012. Ivy Bridge processors will be
backwards-compatible with the Sandy Bridge platform, but require a
BIOS/firmware update. Intel also plans a new 7-series Panther Point
chipsets with Ivy Bridge that will come with integrated USB 3.0.
Due to having no significant obstacles during the new 3D gate
development, Intel planned to begin sale of the processors in the last
quarter of 2011, with retail availability from April 2012. Intel
announced production of Ivy Bridge chips in volume, in preparation for
the product launch, starting in the third quarter of 2011.
VIVEK KANISSERY
Mithun Mathew
Intel Ivy Bridge
Ivy Bridge is the codename for the 22 nm die shrink of Sandy Bridge
Intel plans for retail sale in 2012. Ivy Bridge processors will be
backwards-compatible with the Sandy Bridge platform, but require a
BIOS/firmware update. Intel also plans a new 7-series Panther Point
chipsets with Ivy Bridge that will come with integrated USB 3.0.
Due to having no significant obstacles during the new 3D gate
development, Intel planned to begin sale of the processors in the last
quarter of 2011, with retail availability from April 2012. Intel
announced production of Ivy Bridge chips in volume, in preparation for
the product launch, starting in the third quarter of 2011.
VIVEK KANISSERY